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At 24 hrs the plasma levels of sildenafil ended up even now about 200 ng/mL, when compared with approximately 5 ng/mL when sildenafil was dosed alone. This is certainly in line with ritonavir's marked effects with a wide array of P450 substrates. VIAGRA had no impact on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS